I'd say 75% of my wardrobe was acquired second-hand, either at thrift shops, online, or from my generous sister-in-law's vast closet. One key to successful thrifting is to be well-educated on brands/trends/style, and of course, we all know what a valuable resource YLF is in that regard.
For me, online thrifting takes a different approach from in-store thrifting. I find that online shopping works best when searching for a specific item. If you're looking for, say, white bootcut jeans or a navy fringe jacket, your likelihood of finding them (in your size/preferred brands) online is greater than by stopping into the local thrift shop. On the other hand, shopping in person is more of a discovery process: a way to find pieces you didn't know existed, evaluate brands that have received actual use, and curate a unique wardrobe. You need both an open mind and discipline!