How far would you be traveling? By plane or driving?
I say I lived in AZ for two years, but actually I commuted there for two years. Home on Friday night, out Sunday morning.
My #1, forget any kind of bag you have to carry. It's all got to be on wheels.
#2, make sure you can wheel your case down the aisle of an airplane, that it's not too wide.
#3, I had a small cosmetic bag with a tube of aspirin, cardboard nail file, bandaids, thin compact mirror, tiny tube of lotion (I liked Prescriptives Flight Cream, you could also use it as a moisturizing mask), semi-lipstick. Something that works as a blusher and lip color is awful helpful for waking up your looks.
#4, Don't carry big bottles of shampoo, conditioner, etc. Frankly, I buy stuff like that when I get to the destination. All that security fuss and leakage.
#5, Always be ready to fire up your laptop and take off your shoes for security. So don't bury your laptop in a sleeve in a bag, etc.
#6, They make these fleece plane "sleeping bags" which I found made flights a lot comfier. Also, foot stools; I personally prefer to prop my feet up a bit when I have to sit a long time like that.
#7, I tried taking those homeopathic flight meds to ward off plane germs just once - only time I've ever gotten swollen ankles from flying.
#8, Don't pack clothes for all possibilities. In case of freak rainstorms, just be prepared to go into a drugstore and buy some wonky galoshes.
#9, Small plastic hairbrush that you can also use as a scalp massager to wash your hair is handy.
#10, Travel perfume free.
It can be really hard to have a personal life when you're always on the road. If you're outgoing, you can make friends and dine with them whenever you're in town... but you know, you won't be taking any classes and spending time with friends like on Friends.