Oh, what a timely question, Angie! I hope somebody suggests something, because I just can't find anything that works 100% for me.
The anti-chafing gels help some, but if you sweat a lot, they have to be constantly reapplied -- not an option when you're running around all day long.
Light control shapewear is a good option, except that I can't find a pair of good mid-thigh shorts that do not cut into my flesh. Even shorts with laser-cut edges do that, simply because my thighs are fleshy. The line the shorts create is very obvious under pencil skirts. I most recently tried the Commando thigh shaper, which is great in every respect except for the thigh bind problem. Ack! So for me, the search continues.