My lab has microclimates. Seriously. I think the overall AC is set to typical frigid office building temperature, but there are spots with horrendous drafts (it's an old, crappy building with old, crappy air ducts) and other spots that are super warm due to a lot of machines producing heat.
My desk used to be under one of the drafts but the other place where I spend a lot of time sitting and working is in one of the warm spots. So I was constantly putting things on and taking them off in the lab. Luckily I moved to a different desk a few months ago so it's not so freezing cold there all the time any more.