Nancy, I knoow from research that aside from a tretinoin cream like Retin A or Renova nothing will really effect substantial changes in ageing skin. (Take a look at cosmeticscop.com and Paula Begoun's books and her beautypedia site for reality based advice). I do use Paula' Begoun's antioxidant serum (morning) with Renova in the evening on my neck and face. The serum is more a preventive and to improve skin health and function than for wrinkle or crepey skin repair, but it all helps. In fact all good cosmetics dermatologists say you have to treat any areas that are prone to effects of ageing the same way you do your face, something I was late to learn. I also highly recommend Dr. Brandith Irwin's new book "the No Surgery Makeover" for no-nonsense advice including procedures to address this issue.