I hand wash some things, especially if it's a new thrift store purchase like a scarf. But for the most part everything goes in the machine, in a mesh bag.
I'm fortunate that the hand wash cycle on mine really does little more than soak, and you can set it to no spin at all. I don't have a dryer so everything goes on the line outside or on folding racks indoors, and with the aid of a dehumidifier everything is fine.
I avoid dry clean only stuff because I never go to the cleaners unless it's a once in a blue moon coat cleaning or something like that. That said, I have several items that say the should be dry cleaned and to date I have never ruined anything. I've successfully washed silk scarves, lambs wool, merino, and cashmere without any problems that can't be solved with an iron and a pressing cloth.
Maybe I'm just lucky?