In summer I have to wear cotton or linen. It’s so hot, in the upper 90s for weeks on end, that anything else just doesn’t cut it. Some say cotton gets wet. But it dries, too.
In winter, it’s cold here, but very low humidity. Synthetic tops tend to be staticky. A synthetic blend sweater is a little better in this respect than blouses, but only a little.
For coats, I definitely want pure natural fibers. It’s getting so difficult to find, except at extremely high prices. I manage, sort of, by stalking things, going to discount sites like The Rack and 6pm, and buying used. As I mentioned in another post, I bought from EF Renew, and my takeaway is Buyer Beware. Their idea of “good as new” is not the same as mine.