Heatech layers, and heatech warm-lined pants from Uniqlo. Sometimes separate, sometimes together. Heat holders socks with grippers on the sole. Smartwool merino long sleeve tops from REI.

I get a cold draft on my neck in my current office space, so I always have a scarf at hand. And I find that certain chairs/ seating positions REALLY cut off circulation to the legs and feet, so be careful about that! Also bad posture can inhibit breathing which also impacts circulation and warmth. Make sure you are sitting in an ergonomically supportive way.

I'm in an RV, which means I rack of a heating bill even when it's very targeted heat. I've found that it's nigh impossible to heat the whole RV, so I selectively heat areas as needed.
I close off the bathroom and crank up the ceramic electric heater in there before I shower. After I'm done in the bathroom, I open the doors back up to the rest of the RV and return the heater to it's most minimal setting. This keeps the back rather cozy.
The front room, the main living area, is a beast. Whenever it's stupid cold, I run the propane furnace at its lowest level. This keeps it tolerable and prevents the water lines from freezing, but generally leaves me still quite chilly. I gave up trying to warm the whole room to cozy standards, and now I just put a ceramic electric heater blowing straight on me at the lowest setting. It's way more energy efficient than trying to warm the whole room, and keeps me from having to pile on all the freaking clothes and blankets.
Good base layers up top and throw blanket for legs, plush fabrics, smartwool socks, warm fuzzy slippers, hot cocoa... these all help, but that targeted heating has been the most successful tactic in all my years of fulltime RV living.

We keep our house between 62-65F. I drink hot tea. I wear my Smartwool socks and indoor sneakers or house shoes to keep my toes warm. I often add a blazer, leather jacket or cardigan to my outfit for the day and will put it on or take it off, depending on how warm or cold I feel. I also have a lovely ribbed knit blanket cape that I sometimes drape over my shoulders. On overcast days when the sun is unlikely to warm the room, I add a silk scarf to my outfit,