I do carry my bag around the office, for trips to the bathroom (frequent if I'm drinking too much coffee!), down to the lunchroom, and constantly running between conference rooms and meetings. I am in and out of my bag a lot, since I keep my phone in it, kleenex, chapstick, gum, power bar, scarf, pens, computer adapters, etc. I guess you could say I futz a lot - need a slick of chapstick because my lips are getting dry; my nose is dripping because I get allergies dry office air; there's no pocket for my cell phone today; etc.
For business travel, I am using a nylon laptop/carryon bag with a clutch tucked in. I will pack the laptop bag with cardigan, scarf, flat shoes, etc and then park the laptop bag somewhere. Then grab the clutch in one hand and my MAC in the other as I go from meeting to meeting.
With my old job when I had to go into the office I'd put my heavy PC laptop in an ugly but highly serviceable bag that had rollers. This would greatly ease my back. And carry a nice handbag that I'd swap out depending on my outfit. Now that I have a MAC, I plan to just pop it into a nice sleeve and hand-carry, with everything else in nice handbag. I have two sleeves at the moment, one basic black and the other a fun red. I might be inclined to invest in something stylish!
So even if you aren't a "bag" girl, you can always get stylish with laptop bag or sleeve and have some fun there....
I did look into stylish bags big enough to tote a laptop, but they are HUGE and if not nylon very heavy. I'd rather save my back and carry laptop sleeve in one hand, smaller bag in the other (or across body).